Monday, July 13, 2015

MegaSporeBiotic & the Safety of Bacillus Licheniformis

MegaSporeBiotic is comprised of five verified and tested bacillus strains: bacillus indicus, bacillus subtilis, bacillus clausii, bacillus coagulans, and bacillus licheniformis. To date, some of the most researched and widely used true probiotic strains are from the bacillus species. By utilizing a strong foundation of research and supervision from the pioneering experts in the field of bacteriotherapy, each strain carried heavy consideration prior to inclusion of MegaSporeBiotic’s formula.

The formulation of MegaSporeBiotic has a deliberate ratio for a combined colony-forming unit (CFU) of 4 Billion. With particular attention to Bacillus licheniformis, it is important to note that of all five strains B. licheniformis carries the smallest concentration of bacterial cells - nearly 50 million CFU. With that said, the presence of B. licheniformis in MegaSporeBiotic’s formula is deliberate and thoughtfully measured.

Bacillus Licheniformis as an Organism in Nature

Bacillus licheniformis is a ubiquitous organism exposed and consumed by humans for millions of years. As one the most widely used organisms in the industry, it produces a number of important compounds. One compound, produced both in vitro and in vivo, individuals are most familiar with is the antibiotic bacitracin. B. licheniformis produces this antibiotic in the presence of pathogens and is effective against pathogens like vibrio. It is important to note that bacitracin is a thermostable antibiotic that is resistant to enzymatic degradation, making it extremely effective in the gut. This in vivo antibiotic also helps the function of the main bacillus subtilis antibiotic called subtilisin. Additionally, b. licheniformis produces a stable protease enzyme vital for digesting and assimilating proteins in the body.

B. licheniformis performs several important functions in the gut alongside the other bacillus strains. In the natural environment, bacillus licheniformis is almost always found in consortium with b. subtilis, b. coagulans, etc. and have evolved to work as a partnership. Our ancestors consumed a significant amount of b. Licheniformis together with b. subtilis, b. coagulans, b. clausii and likely b. indicus as well. Exposure to these species over millions of years has become a critical function of our digestive and immune systems. For this reason, MegaSporeBiotic is designed based on both clinical data and the natural environment. The formulation mocks the natural consortium of these species found in nature.

Consumption & Safety of Bacillus Licheniformis as a Probiotic

MegaSporeBiotic has been carefully designed jointly by microbiologists, doctors, and researchers utilizing a significant amount of precaution and safety with regards to the strains/species used. The formulation of MegaSporeBiotic utilized the highest standards of scientific rationale to determine which species to include or exclude. When defining the safety of a particular species for use as a probiotic, conclusions are based on in vivo, controlled safety trials where all variables have been documented. This is true for establishing safety and efficacy. Determination of safety cannot be scientifically made on or by including a small number of non-controlled case studies, especially in cases where variables are unaccounted for.

Each reported research study must be carefully evaluated and examined to determine if the species of concern is the true causative agent. If so, the outlying factors must be identified. Fortunately, numerous researchers have reviewed cases resulting in adverse events with the use of b. licheniformis. After reviewing these published studies it was determined that in none of the cases was b. licheniformis the causative agent. Additionally, all cases were reported having included individuals who were severely immunocompromised or with trauma. Bacillus licheniformis was never determined to be the actual cause of infection, rather only documented as associated as this species is not naturally infective.

With regards to cases associated with cattle or feed products, they cannot be translated to human use. Strains used in feed are exclusively different from the human strain. The reason for the difference is because cattle farms are the breeding ground for mutated, resistant, infectious bacteria. The probiotic strains get mixed with pathogenic strains of E. coli, listeria, salmonella, etc. that are found highly prevalent in these farms where antibiotics are heavily used. Due to the high antibiotic use, pathogens develop resistance and higher virulence.  In turn, these traits can be passed on to the probiotic strains used. This is notably different than the human nutritional environment. 

The most comprehensive safety review on bacillus licheniformis was performed by the Environmental Protection Agency (EPA). It was concluded that, 

B. licheniformis is not a human pathogen nor is it toxigenic. It is unlikely to be confused with related species that are. However, if challenged by large numbers of this microorganism, compromised individuals or those suffering from trauma may be infected[1].”

In response to cases with adverse events, the EPA and other researchers have reviewed each case of reported illness and have come to the conclusion that b. licheniformis could not be determined to be the causative agent, in the case or simply present in the patient, because the strain is widely found in the natural environment. Furthermore, Nithya et al., with the CSIR-Central Food Technological Research Institute, performed a controlled, in vivo safety and toxicological study with b. licheniformis and found it, "safe for food industry applications." 

Bacillus licheniformis is a Generally Recognized as Safe (GRAS) organism in the United States by the Food and Drug Administration (FDA) standard for safety and toxicity of bacterial strains and has Qualified Presumption of Safety (QPS) designation in the European Union (EU).  To date, there is not a single case report where b. licheniformis was determined to be the primary causative agent in an infection and all case reports of adverse events are in subjects that are severely immunocompromised and/or had significant trauma. 


The Research Team & Staff at MegaSporeBiotic™

The philosophy behind MegaSporeBiotic includes scientific evidence, research support, and safety with regards to human consumption. It is our objective to provide the highest quality pharmaceutical probiotic product, while making published research accessible for educated decisions on bacteriotherapy.

Questions? Email us @

[1] United States Environmental Protection Agency. (1997, February). Bacillus Licheniformis Final Risk Assessment. (2015, July). Retrieved from

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Tuesday, October 28, 2014

Why Take Probiotics - A Patient's Understanding

Why Support Digestive & Immune Function with Probiotics?

What Are Probiotics?

Our ancestors had a diet brimming with nutrients and beneficial species of live bacteria because they lived off the land. These species of live bacteria evolved into an essential component of our digestive system known as probiotics. Probiotics regulate the digestive system, improve immune function and serve as the first line of defense against infections.

What if I Don’t Take Probiotics?

Digestive health is paramount to our overall health. An unhealthy digestive system results in an over-growth of bad bacteria and yeast. Food cannot be broken down properly, essential nutrients are not absorbed and the immune system is compromised leaving us fatigued and rundown. Over-growth of bad bacteria leads to a higher risk of infections, allergies, and inflammation, which can lead to symptoms of constipation, diarrhea, gas, bloating, acid reflux disease, eczema and often weight gain.

What Kind of Probiotic Should I Take?

Not all probiotics are created equal. For a probiotic to perform its necessary function, it must naturally survive the stomach’s harsh environment and arrive to the intestines alive. A true probiotic, designed by nature, is a species found in our environment, as well as in our digestive system. Over 95% of probiotic products in the marketplace today do not meet these criteria. To date, the most researched and widely used true probiotic strains are from the bacillus species. MegaSporeBiotic® contains strains that have been proven to impede the growth of unwanted bacteria and yeast, while strengthening the immune response and producing essential nutrients at the site of absorption.  MegaSporeBiotic® is the first probiotic and antioxidant combination sold exclusively through health practitioners.


Your Staff @ Physicians Exclusive: MegaSporeBiotic

Questions? Call 855-729-5090 - We would be happy to speak with you!

Wednesday, July 9, 2014

Production of Carotenoid Antioxidants at RDA Levels with MegaSporeBiotic

Did you know that our Gut Model Study shows that MegaSporeBiotic produces carotenoid antioxidants at RDA levels? Check out our Gut Model Summary here!

"We commissioned and now have completed a very elaborate gut model study of 2 of our main strains (Bacillus Subtilis HU58 and Bacillus Indicus HU36). This study was completed at a contract research company called ProDigest who specialize in digestive studies. The company is a spin-off from Ghent University..."

Wednesday, April 16, 2014

Probiotics for Small Intestine Bacterial Overgrowth

Did you know the strains of bacteria used in MegaSporeBiotic have shown to be clinically effective for small intestine bacterial overgrowth (SIBO)?

What is SIBO?

"The small bowel, also known as the small intestine, is part of the digestive system that connects the stomach with the large bowel or colon. The main purpose of the small intestine is to digest and absorb food into the body. The small bowel is divided into three parts:  the duodenum (which food from the stomach empties into), the jejunum and the ileum (which empties undigested food into the large intestine or colon).

 The entire gastrointestinal tract, including the small intestine, normally contains bacteria. The number of bacteria is greatest in the colon but much lower in the small intestine. Also, the types of bacteria within the small intestine are different to the types of bacteria within the colon. Small intestinal bacterial overgrowth (SIBO) refers to a condition in which abnormally large numbers of bacteria are present in the small intestine, while the types of bacteria found in the small intestine are more like the bacteria found in the colon.

Small intestinal bacterial overgrowth (SIBO) is also known as small bowel bacterial overgrowth syndrome (SBBOS)"[1]. 

Check out the following publication on utilizing Bacillus Clausii as treatment for SIBO.

Do you have Small Intestine Bacterial Overgrowth?

Check out Dr. Amy Myers article on “10 Signs You Have Small Intestinal BacterialOvergrowth (SIBO)

[1] Source:

Thursday, February 13, 2014

Bacteriotherapy as Nature Intended: Discover the Essential Nutrient that can Transform Your Patient’s Health

We all know that modern, processed foods are stripped of most of their nutritive value. An essential, missing nutrient, which unfortunately receives the least attention, is beneficial bacteria, commonly known as probiotics. With more and more patients seeking medical attention for digestive and immune system challenges, and a market flooded with probiotic products that make undeliverable promises, it’s time you learned about the clinically-proven results patients around the nation are experiencing with MegaSporeBiotic—bacteriotheraphy as nature intended.

To understand what makes MegaSporeBiotic the 21st century answer to your patients’ modern-day health challenges, it’s important to remember that our ancestors ate a probiotic-rich diet consisting of locally-grown foods and liquids brimming with mega-doses of environmental bacteria. Most of those bacteria died during transit through the body’s harsh gastric system; but some did not. The strains that survived later co-evolved to withstand both the outside environment, as well as passage through the body’s gastric system, where they ended up thriving in the intestines. These bacteria became nature’s first, “true probiotics." Equipped with the ability to live and reproduce in two very different environs (outside the body and inside the body), these strains were said to have a “biphasic life cycle.”

Today, the most well-known, well-studied, and widely-used biphasic probiotics are from the bacillus species, particularly bacillus subtilis, bacillus clausii, bacillus licheniformis and bacillus coagulans. In addition, a recently discovered and developed strain is bacillus indicus. MegaSporeBiotic is the first product on the market that combines all five of these biphasic strains in clinically-relevant doses, with clinically-proven results.

Studies of glacial ice-cores have found the presence of these bacillus species all over the world, dating back as far as 20-thousand years ago. Over that time period, these bacillus species have retained over 90% genetic homology to the strains used today in MegaSporeBiotic. This means that nature's "True Probiotics" have co-evolved with the the human species to be essential, commensal organisms over at least 20,000 years'
MegaSporeBiotic is the evolutionary bridge between that ancestral heritage and our nation’s modern-day, digestive and immune health crisis, providing some uniquely critical functions:

·   Development of the Gut Associated Lymphoid Tissue (GALT) – besides immune stimulation, bacillus subtilis is believed to be partly responsible for the development of the GALT itself. The GALT makes up 70 percent of the immune system.

·   Stimulation and immune tutoring via the Peyer’s Patches in the upper GI. This is critical to pattern recognition and thus autoimmune and allergenic conditions.

·   Competitive exclusion of bacterial and fungal pathogens. The bacillus species are regulators of the GI microbiota and can actually support the growth of your good bacteria while eliminating the bad.

·   Digestion of starch and non-starch polysaccharides to create healthful short-chain fatty acids (such as acetate, propionate, and butyrate) which have profound implications on risks of gastrointestinal disorders, cancer, and cardiovascular disease.

·   Microbiota balance for SIBO – bacillus clausii is actually used as a prescription treatment for SIBO in over 14 countries. You have it in MegaSporeBiotic.

·   Production of digestive enzymes and vitamins in the digestive tract.

·   Production of the most bioavailable carotenoids – bacillus indicus HU36 is patented for the biological delivery of carotenoids. Once colonized, this strain produces physiologically significant amounts of beta-carotene, alpha-carotene, lutein, lycopene, astaxanthin, zeaxanthin, etc. right at the site of absorption.

·   Detox – these strains neutralize several food borne toxins such as Zearalenone (ZEA) and vomitoxin... and much more!

Based on what we’ve learned, we know that over the course of 20-thousand years of co-evolution, the human body has come to depend on these highly specialized bacteria species as essential nutrients for healthy living. Without them, people experience fatigue, malaise, immune disorders, skin disorders, higher levels of toxicity, dysbiosis, chronic inflammation, and more.

Ready to learn more?

Thursday, January 30, 2014

Welcome to all things MegaSporeBiotic

Welcome to Our Blog!

As we all know from the Human Microbiome Project, the vast amount of recent research on microorganisms in the gastrointestinal tract has created great interest in their connections with overall health. The diversity of these microorganisms create a foundation that directly affect GI health, allergies, autoimmune disease, body weight, energy, and overall health. The survivability of most probiotics available today fail to provide the optimal therapy that we health practitioners require for our patients. Physicians Exclusive would like to introduce you to MegaSporeBiotic, which has provided remarkable support for those patients experiencing a wide range of gastrointestinal, weight, immune and autoimmune issues.

MegaSporeBiotic is a pharmaceutical grade, all-spore formula of five (5) tested and validated strains of Bacillus. Unlike other probiotics, MegaSporeBiotic is remarkable due to its delivery to the site of colonization, proving 100% survivability through the gastric environment. In addition, with the microbiota directly producing carotenes, quinols, B vitamins, and Vitamin K2 directly within the gastrointestinal tract, maximum absorbability is obtained.

Stay tuned to our blog for more updates!


The Physicians Exclusive Team

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